个人简介

申少斐,河北邢台人,新加坡国立大学生物医学工程学院访问学者。从事微流控芯片相关的生命分析方法研究,聚焦于高通量药物筛选系统及微型化诊疗仪器的设计研制。曾获山西省“三晋英才”支持计划青年优秀人才、五四青年标兵、山西农业大学“晋农新秀”和“晋农学者”等荣誉称号。先后主持国家自然科学基金面上和青年项目、山西省基础研究计划（自由探索类）面上项目以及山西省高等学校创新等项目。主持地方标准1项;授权国家发明专利4项;以第一或通讯作者在Microsystems & Nanoengineering、Lab on a Chip、Analytical Chemistry、Sensors and Actuators: B. Chemical等知名期刊发表SCI论文20余篇。担任ACS Nano、Lab on a Chip、Analytical Chemistry、Nano letters、Sensors and Actuators: B. Chemical、Journal of Nanobiotechnology、Physics of Fluids、Chemical Engineering Science、Microfluidics and Nanofluidics等20余个国际学术期刊的审稿人。

教育经历

(1) 2010-09至2016-06, 西北农林科技大学, 化学生物学（保研）, 博士（导师：王进义）

(2) 2006-09至2010-06, 西北农林科技大学, 生物科学, 学士

科研与学术工作经历

(1) 2024-02至 今, 山西农业大学, 生命科学学院, 教授

(2) 2022-12至2023-12, 新加坡国立大学, 生物医学工程学院（导师：Lim Chwee Teck院士）

(3) 2018-12至2024-02, 山西农业大学, 生命科学学院, 副教授

(4) 2016-06至2018-12, 山西农业大学, 生命科学学院, 讲师

代表性研究论文（^# 为共一作者（Equal contributors）；^* 为通讯作者（Correspondence））

(35)Shaofei Shen*, Lei Zhao, Hanjie Bai, Yali Zhang, Yanbing Niu, Chang Tian, Henryk Chan. Spiral Large-Dimension Microfluidic Channel for Flow-Rate- and Particle-Size-Insensitive Focusing by the Stabilization and Acceleration of Secondary Flow. Analytical Chemistry, 2024, 96, 4, 1750−1758. (一区,自然指数期刊)

(34)Tao Tang^#, Hao Zhao^#,Shaofei Shen^#, Like Yang, Chwee Teck Lim*. Enhancing Single-Cell Encapsulation Performance in Droplet Microfluidics with Fine-tunable On-Chip Sample Enrichment. Microsystems & Nanoengineering, 2024,10:3.(一区, 《中国科技期刊卓越行动计划入选项目》领军期刊)

(33)Shaofei Shen*, Yali Zhang, Kai Yang, Henryk Chan, Weiwen Li, Xiaoping Li, Chang Tian*, Yanbing Niu. Flow-rate insensitive plasma extraction by the stabilization and acceleration of secondary flow in the ultra-low aspect ratio spiral channel. Analytical Chemistry, 2023, 95, 18278−18286. (一区,自然指数期刊)

(32)Shaofei Shen*, Hanjie Bai, Xin Wang, Henryk Chan, Yanbing Niu, Weiwen Li, Chang Tian, Xiaoping Li*.High-Throughput Blood Plasma Extraction in a Dimension-Confined Double-Spiral Channel. Analytical Chemistry, 2023, 95: 16649-16658. (一区, 自然指数期刊)

(31)Shaofei Shen*, Fangjuan Zhang, Yali Zhang, Yi Li, Yanbing Niu, Long Pang*, Jinyi Wang*. Construction of multiple concentration gradients for single-cell level drug screening. Microsystems & Nanoengineering, 2023, 9: 46.(一区, 《中国科技期刊卓越行动计划入选项目》领军期刊)

(30)张雅丽,王雪靓,刘翔,赵磊,高建华,王德富,牛颜冰,李毅*,申少斐*.基于低剪切力微流控芯片的细菌长期动态培养及抑菌监测研究. 分析化学, 2023, 9(51): 1483-1493.(中文1A级)

(29) Bi Luo, Jing‑Yun Su, Ya‑Nan Wang, Li Guan, Kai‑Shi Dong, Hui‑Jing Niu, ShaoFei Shen*, Yi Li*.Shewanella subflava sp. nov., a novel multi‑resistant bacterium, isolated from the estuary of the Fenhe River into the Yellow River. Antonie van Leeuwenhoek, 2023, 116: 511-519.(三区)

(28) Fangyuan Wang, Fenxian Zhang, Yi Li, Jianhua Gao, Yanbing Niu, Shaofei Shen*. Fabrication of Bionic Leaf Model and Its Application in Agarose Microfluidic Chip.仿生树叶模型的制作及在琼脂糖微流控芯片中的应用,Chem. J. Chinese Universities, 2022 43(11), 20220445.(《中国科技期刊卓越行动计划入选项目》的梯队期刊)

(27)Lei Zhao, Mengqi Gao, Yanbing Niu, Jianchun Wang*, Shaofei Shen*, Flow-rate and particle-size insensitive inertial focusing in dimension-confined ultra-low aspect ratio spiral microchannel, Sensors and Actuators B: Chemical, 2022, 369, 132284.(一区)

(26)李毅, 张利环, 冯焱, 李宏, 张锋, 白芸, 丁云云, 康美琳, 王雨竹, 雷嘉轩, 申少斐*.基于宏基因组技术解析南极不同纬度地区土壤抗生素抗性基因的分布与迁移.微生物学报, 2021, 61(11): 3744-3756.(中文1A级)

(25)李毅, 夏呈强, 冯焱, 李宏, 张锋, 关丽, 董凯诗, 申少斐*.通过宏基因组分箱方法揭示南极联合冰川土壤中ARG宿主.生态学杂志, 2021, 40(9): 2832-2841.(中文1B级)

(24)Shaofei Shen*, Mengqi Gao, Fangjuan Zhang, Yanbing Niu*. Numerical study of multivortex regulation in curved microchannels with ultra-low-aspect-ratio. Micromachines, 2021, 12(84): 1-13.(三区)

(23)Shaofei Shen*,Xin Wang, Yanbing Niu*. Multi-Vortex Regulation for Efficient Fluid and Particle Manipulation in Ultra-Low Aspect Ratio Curved Microchannels. Micromachines, 2021, 12(758): 1-14.(三区)

(22)Fangjuan Zhang, Haibing Liu, Mengqi Gao, Defu Wang, Yanbing Niu, Shaofei Shen*. Concentration-Gradient Microfluidic Chips for Drug Screening. Progress in chemistry 2021, 33(7): 1138-1151.(三区)

(21)Shaofei Shen¹*, Xuan Zhang¹, Fangjuan Zhang, Defu Wang, Dandan Long, Yanbing Niu*. Three-gradient constructions in a flow-rate insensitive microfluidic system for drug screening towards personalized treatment. Talanta, 2020, 208, 120477.(一区)

(20)Shaofei Shen¹*, Fangjuan Zhang¹, Mengqi Gao, Yanbing Niu*. Concentration gradient constructions using inertial microfluidics for studying tumor cell-drug interactions. Micromachines, 2020, 11(5): 1-13.(三区)

(19)Shaofei Shen*, Fangjuan Zhang, Shuting Wang, Jiangran Wang, Dandan Long, Defu Wang, Yanbing Niu*. Ultra-low aspect ratio spiral microchannel with ordered micro-bars for flow rate insensitive blood plasma extraction. Sensors and Actuators B-Chemical, 2019, 287: 320-328.(一区)

(18)Shaofei Shen, Lisha Kou, Xuan Zhang, Defu Wang, Yanbing Niu*, Jinyi Wang*. Regulating secondaryflow in ultra-Low aspect ratio microchannels by dimensional confinement. Advanced Theory and Simulations, 2018, 1700034. ( Inside front cover)(三区)

(17)Shaofei Shen, Chang Tian, Tianbao Li, Juan Xu, Qin Tu, Wenming Liu*, Jinyi Wang*. Spiral microchannel with ordered micro-obstacles for continuous and highly-efficient particle separation. Lab on a Chip, 2017, 17:3578-3591. (Front cover)(一区)

(16)Lei Zhao, Chao Ma, Shaofei Shen, Chang Tian, Juan Xu, Qin Tu, Tianbao Li, Yaolei Wang, Jinyi Wang*, Pneumatic microfluidics-based multiplex single-cell array. Biosensors and Bioelectronics, 2016, 78: 423-430. (一区)

(15)Chao Ma, Lei Zhao, En-Min Zhou, Juan Xu, Shaofei Shen, Jinyi Wang*. On-chip construction of liver lobule-like microtissue and its application for adverse drug reaction assay. Analytical Chemistry, 2016, 88(3): 1719-1727. (一区)

(14)闫嘉航,赵磊,申少斐,马超,王进义^*,液滴微流控技术在生物医学中的应用进展, 分析化学评述与进展：2016, 44(4): 562~568.

(13)Long Pang, Shaofei Shen, Chao Ma, Tongtong Ma, Lei Zhao, Yaolei Wang, Jinyi Wang*. Size-and Deformability-based cancer cell separation in an integrated microfluidic device. Analyst, 2015,140(21): 7335-7346. (二区)

(12)*Wenming Liu, Juan Xu, Tianbao Li, Lei Zhao, Chao Ma, Shaofei Shen, Jinyi Wang*. Monitoring tumor response to anticancer drugs using stable three-dimensional culture in a recyclable microfluidic platform. Analytical Chemistry, 2015, 87(19): 9752-9760. (一区)

(11)马超,申少斐,赵磊,王进义^*,生命分析微流控芯片的多尺度应用：从分子水平到个体水平, 分析测试学报：2015, 34(3): 246~25.

(10)Shaofei Shen, Chao Ma, Lei Zhao, Yaolei Wang, Jian-Chun Wang, Juan Xu, Tianbao Li, Long Pang, Jinyi Wang*. High-throughput rare cell separation from blood samples using steric hindrance and inertial microfluidics. Lab on a Chip, 2014, 14(14): 2525-2538. (一区)

(9)Juan Xu, Tianbao Li, Shaofei Shen, Lei Zhao, Chao Ma, Abd Elaal Mahmoud and Jinyi Wang*. Electrochemically Reduced Carboxyl Graphene Modified Electrode for Simultaneous Determination of Guanine and Adenine. Analytical Letters, 2014, 48(9): 1465-1480.

(8)Tianbao Li, Juan Xu, Ling Zhou, Shaofei Shen, Lei Zhao, Maosen Yuan, Jinyi Wang*. Carboxyl hydrogel particle film as a proton source for electrode surface modification. Electrochemstry Communication, 2014, 38(1): 75-78.

(7)Tianbao Li, Juan Xu, Lei Zhao, Shaofei Shen, Maoshen Yuan, Jinyi Wang*, Voltammetric behavior of carboxyl hydrogel particles on a cavity electrode surface, Electrochimicam Acta, 2014, 130(130): 22-28.

(6)Juan Xu, Tianbao Li, Lingli Wang, Jian-Chun Wang, Lei Zhao, Shaofei Shen, Qin Tu, Yanrong Zhang, Jinyi Wang*. Voltammetric Behavior of Guanine at ERGO/GC Electrode and its Application in Cell Counting. Journal of The Electrochemical Society, 2014,161(4): G21-G25.

(5)Li Ren, Wenming Liu, Yaolei Wang, Jian- Chun Wang, Qin Tu, Juan Xu, Rui Liu, Shaofei Shen, Jinyi Wang*. Investigation of hypoxia-induced myocardial injury dynamics in a tissue interface mimicking microfluidic device. Analytical Chemistry, 2013, 85(1): 235-244.(一区)

(4)Jian-Chun Wang, Qin Tu, Yaolei Wang, Wenming Liu, Rui Liu, Shaofei Shen, Juan Xu, Lei Zhao, Jinyi Wang*. Pneumatic mold-aided construction of a three-dimensional hydrogel microvascular network in an integrated microfluidics and assay of cancer cell adhesion onto the endothelium. Microfluidics and Nanofluidics, 2013, 15(4): 519-532.

(3)A-Jing Liu, Wenming Liu, Yaolei Wang, Jianchun Wang, Qin Tu, Rui Liu, juan Xu, Shaofei Shen, Jinyi Wang*. Microvalve and liquid membrane double-controlled integrated microfluidics for observing the interaction of breast cancer cells. Microfluidics and Nanofluidics, 2013, 14(3): 515-526.

(2)Qin Tu, Jian-Chun Wang, Rui Liu, Juan He, Yanrong Zhang, Shaofei Shen, Juan Xu, Jianjun Liu, Maosen Yuan, Jinyi Wang*. Antifouling properties of poly(dimethylsiloxane) surfaces modified with quaternized poly(dimethylaminoethyl methacrylate). Colloids and Surfaces B: Biointerfaces, 2013, 102(1): 361-370.

(1)Qin Tu, Jian-Chun Wang, Yanrong Zhang, Rui Liu, Wenming Liu, Li Ren, Shaofei Shen, Juan Xu, Lei Zhao, Jinyi Wang*. Surface modification of poly(dimethylsiloxane) and its applications in microfluidics-based biological analysis. Reviews in Analytical Chemistry, 2012, 31(3-4): 177-192.

授权国家发明专利

申少斐刘亚君侯文慧王德富李玲玉牛颜冰.一种含有牡丹籽油的止痒抑菌软膏及其制备方法 授权公告号：CN 111228344 B专利号：ZL202010125067.3时间2022.03.29

申少斐刘亚君王德富张璐龙丹丹李玲玉牛颜冰.一种牡丹花粉口含片及其制备工艺 授权公告号：CN 110651980 B专利号：ZL 201910950084.8时间2023.05.16

申少斐马瑞华张凤吴婉莹牛颜冰.一种含牡丹籽油的油茶面及其制备方法 授权公告号：CN 113974164 B专利号：ZL20211283359.0时间2023.05.26

申少斐王方圆牛颜冰.一种仿生树叶模型及其制备方法和应用 授权公告号：CN 113942154 B专利号：ZL202111135975.1时间2023.09.12

代表性科研项目

国家自然科学基金面上项目“基于微流控芯片的跨尺度循环肿瘤标志物协同分选检测研究”(82372143);2024/01-2027/12主持

国家自然科学基金青年项目“基于微流控芯片的循环肿瘤细胞及肿瘤干细胞无鞘液流分选检测研究”(31700749); 2018/01-2020/12主持

国家自然科学基金面上项目“肿瘤淋巴转移微流控芯片模型及间质液流对肿瘤淋巴转移的影响” (21375106); 参加

国家自然科学基金面上项目“集成微流控大规模神经网络式脑缺血模型构建及轴突变性分子机制研究应用” (31470971);参加

山西省基础研究计划（自由探索类）项目“基于微流控芯片的微纳尺度样品高效操控技术研究” (20210302123368)。2022.01-2024.12;主持

山西省高等学校科技创新项目“基于惯性微流控芯片的循环肿瘤细胞分选与检测研究” (2019L0362)。2019.07-2021.07;主持

教学所获奖项

国家级一流本科课程（植物学,线下一流课程）梁建萍、申少斐、杨珍平、王卫锋,2023年 第二名

省级高校一流（精品）课立项认定课程（植物学）,2020年第二名

梁建萍、杨珍平、乔永刚、申少斐、王卫锋,山西省教学成果特等奖（高等教育）,农科院校植物学精品课程特色化建设与实践,山西省教育厅,2019年

地方标准

《油用牡丹栽培技术规程》 DB14/T2091-2020申少斐、吕晋慧、牛颜冰、王德富、郭伟、陈煜

学生培养

研究生：2017级张璇（发表一区Top Talanta一篇）; 2018级张芳娟（2020年优秀研究生，发表一区Top Microsystems & Nanoengineering一篇）; 2019级高梦琪（发表一区Top Sensors and Actuators B: Chemical一篇）; 2020级王鑫和2022级白汉洁（合作发表一区Top Analytical Chemistry一篇）; 2021级张雅丽（2023年优秀研究生，发表一区Top Analytical Chemistry一篇）; 2022级白汉洁（2023年优秀研究生，山西省教育厅2023年度研究生教育创新计划立项 微结构辅助的螺旋管道构建及细胞三维聚焦研究）

本科生：2015级侯文慧（授权发明专利一项）; 2015级张璐（授权发明专利一项）; 2016级王露（发表中文期刊一篇山西农业科学）; 2017级王雪靓（保研西北工业大学,合作发表中文期刊1A一篇）; 2017级马瑞华张凤吴婉莹（授权发明专利一项）; 2017级刘卓欣（保研湖南大学）; 2018级刘海兵（立项省级大学生创业创新项目基于微流控的油用牡丹籽粕抗菌研究,合作发表SCI三区一篇,院级优秀毕业论文）; 2018级刘绪芳（保研中南大学,撰写一篇SCI在投,院级优秀毕业论文）; 2018级王方圆（发表中国科技期刊卓越行动计划入选项目梯队期刊一篇,授权发明专利一项）; 2018级苏玫匀（院级优秀毕业论文,考研到安徽中医药大学）; 2018级杨开（校级和院级优秀毕业论文,合作发表中科院一区一篇,负责底稿撰写和示意图）; 2019级张奋娴（院级优秀毕业论文）; 2020级林智慧（立项省级和校级大学生创业创新项目各一项基于微流控芯片的牡丹蛋白/壳聚糖/牡丹籽油微胶囊制备技术研究）; 2020级马怡馨（保研兰州大学）; 2021级郭时超（立项省级大学生创业创新项目一项基于微流控芯片的SOD/视黄醇衍生物微胶囊制备技术研究）

欢迎不同专业背景,并具有科研热情的同学加入本课题组,有机器学习算法基础的优先考虑。