个人简介:
张媛媛,汉族,山西运城人,中共党员,理学博士,硕士生导师。2020年7月参加工作,现任山西农业大学生命科学学院讲师。
教育背景:
2011.09-2015.06,山西农业大学,植物保护,学士
2015.09-2020.06,中国农业大学,化学,硕博
工作经历
2020.07~至今山西农业大学,生命科学学院,讲师
研究方向:
荧光探针用于重金属离子、活性氧、酶、核酸等的检测、细胞定位及生物成像研究,载药型荧光探针构建
发表论文:
1. Zhang Y, Chen X, Liu X, et al. A highly sensitive multifunctional sensor based on phenylene-acetylene for colorimetric detection of Fe2+ and ratiometric fluorescent detection of Cd2+ and Zn2+. Sens. Actuators, B., 2018, 273, 1077-1084.
2. Zhang Y, Chen X, Liu X, et al. A highly selective and ultrafast near-infrared fluorescent turn-on and colorimetric probe for hypochlorite in living cells. Anal. Chim. Acta., 2019, 1078, 135-141.
3. Zhang Y, Chen X, Liu J, et al. A highly selective and sensitive fluorescent chemosensor for distinguishing cadmium (II) from zinc (II) based on amide tautomerization. New J. Chem., 2018, 42, 19245-19251.
4. Zhang Y, Ma Y, Wang Z, et al. A novel colorimetric and far-red emission ratiometric fluorescent probe for the highly selective and ultrafast detection of hypochlorite in water and its application in bioimaging. Analyst., 2020,145, 939-945.
5. Chen X, Ma X, Zhang Y, et al. Ratiometric fluorescent probes with a self-immolative spacer for real-time detection of β-galactosidase and imaging in living cells. Anal. Chim. Acta., 2018, 1033, 193-198.
6. Liu J, Chen X, Zhang Y, et al. A novel 3-hydroxychromone fluorescent probe for hydrogen sulfide based on an excited-state intramolecular proton transfer mechanism. New J. Chem., 2018, 42, 12918-12923.
7. Liu J, Chen X, Zhang Y, et al. A novel xanthene-based colorimetric and fluorescence probe for detection of H2S in living cells. J. Lumin., 2018, 204, 480-484.
8. Zhang X, Chen X, Zhang Y, et al. A high-sensitivity fluorescent probe with a selfimmolative spacer for real-time radiometric detection and imaging of alkaline phosphatase activity. New J. Chem., 2019, 43, 11887-11892.
9. Chen X, Zhang X, Ma X, Zhang Y, et al. Novel fluorescent probe for rapid and ratiometric detection of β-galactosidase and live cell imaging. Talanta., 2019, 192, 308-313.
10. Chen X, Wang H, Ma X, Wang M, Zhang Y, et al. Colorimetric and fluorescent probe for real-time detection of palladium (II) ion in aqueous medium and live cell imaging. Dyes Pigm., 2018, 148, 286-291.
11. Zhang X, Chen X, Liu K, Zhang Y, et al. Near-infrared ratiometric probe with a self-immolative spacer for rapid and sensitive detection of alkaline phosphatase activity and imaging in vivo. DOI: 10.1016/j.aca.2019.10.001.
12. Chen X, Ma X, Wang H, Wang M, Zhang Y, et al. A coumarin-based colorimetric and fluorescent dual probe for palladium (II) ions that can be used in live cells. New J. Chem., 2017, 41, 8026-8030.
科研项目
1.山西省高等学校科技创新项目,基于ICT机理的三联吡啶型多功能重金属离子荧光探针构建及应用研究,2021.09-2023.09,主持。
2.山西省博士毕业生来晋工作奖励资金科研项目,比率型Hg2+荧光探针的构建及其在环境分析和生物成像领域的应用研究,2021.04-2023.03,主持。
3.山西农业大学科技创新基金项目,分子荧光探针的构建及其在环境分析和生物成像领域的应用研究,2020.09-2023.09,主持。
4.国家自然科学基金面上项目,基于靶点“钩钓”策略的苦参碱抗PRRSV作用机制研究,2022.01-2025.12,参与。
专利:
1. 发明专利:郑冰,高贵,陈相助,张媛媛,侯士聪,王敏. 一种阿莫曲坦的合成方法,ZL 201511022378.2
2. 发明专利:侯士聪,高贵,陈相助,刘晶晶,张媛媛,张雪焱. 5-氨基吡唑类化合物在调节植物生长方面的应用,ZL201711326981.9
联系方式:zhangyyuan0221@sxau.edu.cn